3h3d: Difference between revisions

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{{Seed}}
[[Image:3h3d.png|left|200px]]


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==Drosophila Pumilio RNA binding domain (Puf domain)==
The line below this paragraph, containing "STRUCTURE_3h3d", creates the "Structure Box" on the page.
<StructureSection load='3h3d' size='340' side='right'caption='[[3h3d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3h3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H3D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h3d OCA], [https://pdbe.org/3h3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h3d RCSB], [https://www.ebi.ac.uk/pdbsum/3h3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h3d ProSAT]</span></td></tr>
{{STRUCTURE_3h3d|  PDB=3h3d  |  SCENE=  }}
</table>
 
== Function ==
===Drosophila Pumilio RNA binding domain (Puf domain)===
[https://www.uniprot.org/uniprot/PUM_DROME PUM_DROME] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Required for abdominal development and to support proliferation and self-renewal of germ cells. Pum is the only gene required for nos activity that is not also required for posterior localization of germline determinants. Pum is required during embryogenesis when nos activity apparently moves anteriorly from the posterior pole.<ref>PMID:1459455</ref> <ref>PMID:1576962</ref> <ref>PMID:9660969</ref>  
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/3h3d_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11336677}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h3d ConSurf].
3H3D is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H3D OCA].  
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== References ==
==Reference==
<references/>
<ref group="xtra">PMID:11336677</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Aggarwal, A K.]]
[[Category: Large Structures]]
[[Category: Edwards, T A.]]
[[Category: Aggarwal AK]]
[[Category: Wharton, R P.]]
[[Category: Edwards TA]]
[[Category: Alternative splicing]]
[[Category: Wharton RP]]
[[Category: Cytoplasm]]
[[Category: Developmental protein]]
[[Category: Phosphoprotein]]
[[Category: Puf]]
[[Category: Pumilio]]
[[Category: Repressor]]
[[Category: Rna binding domain]]
[[Category: Rna binding protein]]
[[Category: Rna-binding]]
[[Category: Translation regulation]]
 
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