3h3d: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 3h3d is ON HOLD
+==Drosophila Pumilio RNA binding domain (Puf domain)==
+<StructureSection load='3h3d' size='340' side='right'caption='[[3h3d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Edwards, T.A., Aggarwal, A.K., Wharton, R.P., Pyle, S.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3h3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H3D FirstGlance]. <br>
-Description: Drosophila Pumilio RNA binding domain (Puf domain)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h3d OCA], [https://pdbe.org/3h3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h3d RCSB], [https://www.ebi.ac.uk/pdbsum/3h3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h3d ProSAT]</span></td></tr>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 11:10:22 2009''
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PUM_DROME PUM_DROME] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Required for abdominal development and to support proliferation and self-renewal of germ cells. Pum is the only gene required for nos activity that is not also required for posterior localization of germline determinants. Pum is required during embryogenesis when nos activity apparently moves anteriorly from the posterior pole.<ref>PMID:1459455</ref> <ref>PMID:1576962</ref> <ref>PMID:9660969</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/3h3d_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h3d ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Drosophila melanogaster]]
+[[Category: Large Structures]]
+[[Category: Aggarwal AK]]
+[[Category: Edwards TA]]
+[[Category: Wharton RP]]