3ggq: Difference between revisions

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<StructureSection load='3ggq' size='340' side='right'caption='[[3ggq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3ggq' size='340' side='right'caption='[[3ggq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hev-1 Hev-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_E_virus_(strain_Pakistan) Hepatitis E virus (strain Pakistan)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 HEV-1])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [https://pdbe.org/3ggq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [https://www.ebi.ac.uk/pdbsum/3ggq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [https://pdbe.org/3ggq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [https://www.ebi.ac.uk/pdbsum/3ggq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CAPSD_HEVPA CAPSD_HEVPA]] Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).  
[https://www.uniprot.org/uniprot/CAPSD_HEVPA CAPSD_HEVPA] Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ggq ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ggq ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Hepatitis E virus (HEV), a non-enveloped, positive-stranded RNA virus, is transmitted in a faecal-oral manner, and causes acute liver diseases in humans. The HEV capsid is made up of capsomeres consisting of homodimers of a single structural capsid protein forming the virus shell. These dimers are believed to protrude from the viral surface and to interact with host cells to initiate infection. To date, no structural information is available for any of the HEV proteins. Here, we report for the first time the crystal structure of the HEV capsid protein domain E2s, a protruding domain, together with functional studies to illustrate that this domain forms a tight homodimer and that this dimerization is essential for HEV-host interactions. In addition, we also show that the neutralizing antibody recognition site of HEV is located on the E2s domain. Our study will aid in the development of vaccines and, subsequently, specific inhibitors for HEV.
Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction.,Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J, Xia N PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7. PMID:19662165<ref>PMID:19662165</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ggq" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hev-1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Du, H L]]
[[Category: Du HL]]
[[Category: Gu, Y]]
[[Category: Gu Y]]
[[Category: Hew, C L]]
[[Category: Hew CL]]
[[Category: Li, S W]]
[[Category: Li SW]]
[[Category: Seetharaman, J]]
[[Category: Seetharaman J]]
[[Category: Shih, J W.K]]
[[Category: Shih JWK]]
[[Category: Sivaraman, J]]
[[Category: Sivaraman J]]
[[Category: Tang, X H]]
[[Category: Tang XH]]
[[Category: Xia, N S]]
[[Category: Xia NS]]
[[Category: Yang, C Y]]
[[Category: Yang CY]]
[[Category: Zhang, J]]
[[Category: Zhang J]]
[[Category: Beta barrel]]
[[Category: Capsid protein]]
[[Category: Rna-binding]]
[[Category: Viral protein]]

Latest revision as of 11:26, 20 March 2024

Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host InteractionDimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction

Structural highlights

3ggq is a 1 chain structure with sequence from Hepatitis E virus (strain Pakistan). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAPSD_HEVPA Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ggq, resolution 2.00Å

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OCA
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