3fxq: Difference between revisions

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[[Image:3fxq.png|left|200px]]


{{STRUCTURE_3fxq|  PDB=3fxq  |  SCENE=  }}
==Crystal structure of the LysR-type transcriptional regulator TsaR==
 
<StructureSection load='3fxq' size='340' side='right'caption='[[3fxq]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
===Crystal structure of the LysR-type transcriptional regulator TsaR===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3fxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FXQ FirstGlance]. <br>
{{ABSTRACT_PUBMED_20059681}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fxq OCA], [https://pdbe.org/3fxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fxq RCSB], [https://www.ebi.ac.uk/pdbsum/3fxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fxq ProSAT]</span></td></tr>
[[3fxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXQ OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/TSAR_COMTE TSAR_COMTE] Regulates expression of the tsaMBCD1 operon and of tsaT in response to p-toluenesulfonate (TSA). Acts by binding directly to the promoter region. Binding to the tsa promoter depends on TSA concentration.<ref>PMID:12676713</ref> <ref>PMID:13680097</ref>
<ref group="xtra">PMID:020059681</ref><ref group="xtra">PMID:018678953</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/3fxq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fxq ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Comamonas testosteroni]]
[[Category: Comamonas testosteroni]]
[[Category: Kertesz, M A.]]
[[Category: Large Structures]]
[[Category: Kikhney, A.]]
[[Category: Kertesz MA]]
[[Category: Monferrer, D.]]
[[Category: Kikhney A]]
[[Category: Svergun, D.]]
[[Category: Monferrer D]]
[[Category: Tralau, T.]]
[[Category: Svergun D]]
[[Category: Uson, I.]]
[[Category: Tralau T]]
[[Category: Dna-binding]]
[[Category: Uson I]]
[[Category: Lttr]]
[[Category: Lysr-type]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulator]]
[[Category: Transcriptional regulator]]
[[Category: Tsar]]
[[Category: Whth]]

Latest revision as of 11:25, 20 March 2024

Crystal structure of the LysR-type transcriptional regulator TsaRCrystal structure of the LysR-type transcriptional regulator TsaR

Structural highlights

3fxq is a 2 chain structure with sequence from Comamonas testosteroni. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TSAR_COMTE Regulates expression of the tsaMBCD1 operon and of tsaT in response to p-toluenesulfonate (TSA). Acts by binding directly to the promoter region. Binding to the tsa promoter depends on TSA concentration.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Tralau T, Mampel J, Cook AM, Ruff J. Characterization of TsaR, an oxygen-sensitive LysR-type regulator for the degradation of p-toluenesulfonate in Comamonas testosteroni T-2. Appl Environ Microbiol. 2003 Apr;69(4):2298-305. PMID:12676713 doi:10.1128/AEM.69.4.2298-2305.2003
  2. ↑ Tralau T, Cook AM, Ruff J. An additional regulator, TsaQ, is involved with TsaR in regulation of transport during the degradation of p-toluenesulfonate in Comamonas testosteroni T-2. Arch Microbiol. 2003 Nov;180(5):319-26. PMID:13680097 doi:10.1007/s00203-003-0594-8

3fxq, resolution 1.85Å

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