3eor: Difference between revisions

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-{{Seed}}
-[[Image:3eor.png|left|200px]]
-<!--
+==Crystal structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with ligand==
-The line below this paragraph, containing "STRUCTURE_3eor", creates the "Structure Box" on the page.
+<StructureSection load='3eor' size='340' side='right'caption='[[3eor]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3eor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EOR FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CFV:[(2R)-1-(4-AMINO-2-OXO-PYRIMIDIN-1-YL)-3-HYDROXY-PROPAN-2-YL]OXYMETHYLPHOSPHONIC+ACID'>CFV</scene>, <scene name='pdbligand=GPP:GERANYL+DIPHOSPHATE'>GPP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3eor|  PDB=3eor  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eor OCA], [https://pdbe.org/3eor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eor RCSB], [https://www.ebi.ac.uk/pdbsum/3eor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eor ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ISPF_ECOLI ISPF_ECOLI] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Also converts 4-diphosphocytidyl-2-C-methyl-D-erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP.<ref>PMID:10694574</ref> <ref>PMID:22839733</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eor_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eor ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with ligand===
+==See Also==
+*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_19320487}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 19320487 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Escherichia coli K-12]]
-{{ABSTRACT_PUBMED_19320487}}
+[[Category: Large Structures]]
+[[Category: Dawson A]]
-==About this Structure==
+[[Category: Hunter WN]]
-EOR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOR OCA].
+[[Category: Ramsden NL]]
-==Reference==
-<ref group="xtra">PMID:19320487</ref><references group="xtra"/>
-[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
-[[Category: Escherichia coli k-12]]
-[[Category: Dawson, A.]]
-[[Category: Hunter, W N.]]
-[[Category: Ramsden, N L.]]
-[[Category: Isoprene biosynthesis]]
-[[Category: Lyase]]
-[[Category: Lysase]]
-[[Category: Magnesium]]
-[[Category: Manganese]]
-[[Category: Mecdp-synthase]]
-[[Category: Metal-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:23:41 2009''