3ddt: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:3ddt.png|left|200px]]
-{{STRUCTURE_3ddt|  PDB=3ddt  |  SCENE=  }}
+==Crystal structure of the B2 box from MuRF1 in dimeric state==
+<StructureSection load='3ddt' size='340' side='right'caption='[[3ddt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DDT FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [https://pdbe.org/3ddt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [https://www.ebi.ac.uk/pdbsum/3ddt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ddt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/3ddt_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ddt ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of the B2 box from MuRF1 in dimeric state===
+==See Also==
+*[[Mur ligase|Mur ligase]]
-{{ABSTRACT_PUBMED_18795805}}
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-[[3ddt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA].
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:018795805</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Mayans, O.]]
+[[Category: Large Structures]]
-[[Category: Mrosek, M.]]
+[[Category: Mayans O]]
-[[Category: Ligase]]
+[[Category: Mrosek M]]
-[[Category: Metal-binding]]
-[[Category: Muscle protein]]
-[[Category: Nucleus]]
-[[Category: Ring-like fold]]
-[[Category: Ubl conjugation pathway]]
-[[Category: Zinc-binding motif]]
-[[Category: Zinc-finger]]