8s9l: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8s9l is ON HOLD  until Paper Publication
+==Structure of monomeric FAM111A SPD V347D Mutant==
+<StructureSection load='8s9l' size='340' side='right'caption='[[8s9l]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors: Palani, S., Alvey, J.A., Cong, A.T.Q., Schellenberg, M.J., Machida, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8s9l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S9L FirstGlance]. <br>
-Description: Structure of monomeric FAM111A SPD V347D Mutant
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Palani, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s9l OCA], [https://pdbe.org/8s9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s9l RCSB], [https://www.ebi.ac.uk/pdbsum/8s9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s9l ProSAT]</span></td></tr>
-[[Category: Machida, Y]]
+</table>
-[[Category: Schellenberg, M.J]]
+== Disease ==
-[[Category: Alvey, J.A]]
+[https://www.uniprot.org/uniprot/F111A_HUMAN F111A_HUMAN] Autosomal dominant Kenny-Caffey syndrome;Osteocraniostenosis. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
-[[Category: Cong, A.T.Q]]
+== Function ==
+[https://www.uniprot.org/uniprot/F111A_HUMAN F111A_HUMAN] Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:32165630). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:32165630). Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors (PubMed:32165630). Required for PCNA loading on replication sites (PubMed:24561620). Promotes S-phase entry and DNA synthesis (PubMed:24561620). Acts also as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus (PubMed:23093934, PubMed:37607234). Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity (PubMed:33369867, PubMed:37607234). In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy (PubMed:37607234).<ref>PMID:24561620</ref> <ref>PMID:32165630</ref> <ref>PMID:37607234</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Alvey JA]]
+[[Category: Cong ATQ]]
+[[Category: Machida Y]]
+[[Category: Palani S]]
+[[Category: Schellenberg MJ]]