Vinculin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel

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-[[Image:1tr2.png|left|200px|thumb|Crystal structure of human full-length Vinculin, [[1tr2]]]]
+<StructureSection load='1st6' size='340' side='right' caption='Chicken full-length metavinculin, [[1st6]]' scene='' >
-{{STRUCTURE_1tr2|  PDB=1tr2  | SIZE=300| SCENE= |right|CAPTION=Human full-length Vinculin, [[1tr2]] }}
+== Function ==
+[[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to [[Actinin|alpha-actinin]] at their respective VCL Binding Sites (VBS)<ref>PMID:11152287</ref>.  The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL.  '''Metavinculin''' (m-VCL) is a splice version of VCL containing an extra ca. 70 amino acids in the C-terminal domain.
-'''Vinculin'''
+== Relevance ==
+Loss of VCL could be used as a prognostic factor for colorectal cancer se it promotes metastasis<ref>PMID:25496021</ref>.
-'''Vinculin (VCL)''' is involved in adhesion by linking integrin molecules to the actin cytoskeleton.  Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS).  A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL.
+== Disease ==
+Mutation in m-VCL can yield cardiomyopathic phenotype<ref>PMID:16236538</ref>.
+== Structural highlights ==
+<scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition.
 == 3D Structures of Vinculin ==
+[[Vinculin 3D structures]]
+==References==
-[[3myi]] – m-VCL tail domain – human<br />
+<references />
-[[3h2u]] – hVCL Vd1 + raver1 RRM<br />
+</StructureSection>
-[[2h2v]] - hVCL C-terminal + raver1 RRM<br />
+[[Category:Topic Page]]
-[[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from Shigella flexneri<br />
-[[2gdc]] – cm-VCL Vd1+SfInvasin C-terminal – chicken<br />
+*Created with the participation of [[User:Susan Craig|Susan Craig]].
-[[1tr2]] – hVCL<br />
-[[1xwj]] - cm-VCL Vd1+cTalin VBS3<br />
-[[1zvz]], [[1zw2]], [[1zw3]], [[1u6h]] - cm-VCL Vd1+cTalin rod<br />
-[[1ydi]] - hVCL Vd1+hActinin VBS<br />
-[[1t01]] - cVCL Vd1+mTalin VBS – mouse<br />
-[[1st6]] – cm-VCL<br />
-[[1syq]], [[1rkc]], [[1rke]] – hVCL Vd1+hTalin VBS<br />
-[[1qkr]] – hVCL C-terminal<br />