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| <StructureSection load='3pih' size='3 | | <StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='53/536710/Cv/3' > |
| 50' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' >
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| == Function == | | == Function == |
| '''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> | | '''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> |
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| == Structural highlights == | | == Structural highlights == |
| UvrA contains several domains: <scene name='53/536710/Cv/1'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>. | | UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>. |
| </StructureSection>
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| ==3D structures of UvrABC== | | ==3D structures of UvrABC== |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | [[UvrABC 3D structures]] |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *UvrA
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| **[[3pih]] – TmUvrA + DNA – ''Thermotoga maritima'' <br />
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| **[[3zqj]] – UvrA – ''Mycobacterium tuberculosis''<br />
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| **[[4dfc]] – EcUvrA + Transcription-repair-coupling factor – ''Escherichia coli'' <br />
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| **[[2r6f]] – BstUvrA – ''Bacillus stearothermophilus'' <br />
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| **[[3ux8]] – GeUvrA - ''Geobacillus''<br />
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| **[[2vf7]], [[2vf8]] – DrUvrA2 - ''Deinococcus radiodurans''<br />
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| *UvrB
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| **[[1d2m]], [[1c4o]] – UvrB – ''Thermus thermophilus'' <br />
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| **[[1d9x]] – BcUvrB – ''Bacillus caldotenax'' <br />
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| **[[1t5l]] – BcUvrB (mutant) <br />
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| **[[1qoj]] – EcUvrB C terminal <br />
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| **[[1e52]] – EcUvrB C terminal - NMR<br />
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| **[[1d9z]] – BcUvrB + ATP <br />
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| **[[2fdc]] – BcUvrB + DNA <br />
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| **[[2d7d]], [[2nmv]], [[3v4r]] – BsUvrB + DNA – ''Bacillus subtilis'' <br />
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| *UvrC
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| **[[1kft]], [[1qoj]] – EcUvrC C terminal <br />
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| **[[1e52]] – EcUvrC C terminal - NMR<br />
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| **[[2nrr]], [[2nrt]], [[2nrv]], [[2nrw]], [[2nrx]], [[2nrz]] – TmUvrC C terminal <br />
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| **[[1ycz]], [[1yd0]], [[1yd1]] – TmUvrC N terminal <br />
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| **[[1yd2]], [[1yd3]], [[1yd4]], [[1yd5]] – TmUvrC N terminal (mutant)<br />
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| **[[1yd6]] – BcUvrC N terminal <br />
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| **[[3c65]] – BstUvrC <br />
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| *UvrD or DNA helicase II see [[Helicase]]
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| *UvrA-UvrB
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| **[[3fpn]] – BstUvrA + UvrB <br />
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| **[[3uwx]] – GeUvrA + UvrB <br />
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| }}
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| ==References== | | ==References== |
| <references /> | | <references /> |
| | </StructureSection> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |