UvrABC: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='53/536710/Cv/3' >
+== Function ==
+'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair.  UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />
+*  '''UvrA''' is the protein which locates the DNA damage<ref>PMID:21240268</ref>.<br />
+*  '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br />
+*  The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>.
+*  '''UvrD''' is '''DNA helicase II'''.  See [[Helicase]].
-{{STRUCTURE_3pih|  PDB=3pih  | SIZE=400| SCENE= |right|CAPTION= UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]] }}
+For details on the UvrA-UvrB complex see [[UvrA-UvrB interaction domains]].
-'''UvrABC''' endonuclease is an E. coli enzyme complex involved in DNA repair.  UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one.  For details on the UvrA-UvrB complex see [[UvrA-UvrB interaction domains]].
+== Structural highlights ==
+UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>.
 ==3D structures of UvrABC==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[UvrABC 3D structures]]
-===UvrA===
-[[3pih]] – TmUvrA + DNA – ''Thermotoga maritima'' <br />
-[[3zqj]] – UvrA  – ''Mycobacterium tuberculosis''<br />
-[[4dfc]] – EcUvrA + Transcription-repair-coupling factor – ''Escherichia coli'' <br />
-[[2r6f]] – BstUvrA – ''Bacillus stearothermophilus'' <br />
-[[3ux8]] – GeUvrA - ''Geobacillus''<br />
-===UvrB===
-[[1d2m]], [[1c4o]] – UvrB – ''Thermus thermophilus'' <br />
-[[1d9x]] – BcUvrB – ''Bacillus caldotenax'' <br />
-[[1t5l]] – BcUvrB (mutant) <br />
-[[1qoj]] – EcUvrB C terminal <br />
-[[1e52]] – EcUvrB C terminal - NMR<br />
-[[1d9z]] – BcUvrB + ATP <br />
-[[2fdc]] – BcUvrB + DNA <br />
-[[2d7d]], [[2nmv]], [[3v4r]] – BsUvrB + DNA – ''Bacillus subtilis'' <br />
-===UvrC===
-[[1kft]] – EcUvrC C terminal <br />
-[[2nrr]], [[2nrt]], [[2nrv]], [[2nrw]], [[2nrx]], [[2nrz]] – TmUvrC C terminal <br />
-[[1ycz]], [[1yd0]], [[1yd1]] – TmUvrC N terminal <br />
-[[1yd2]], [[1yd3]], [[1yd4]], [[1yd5]] – TmUvrC N terminal (mutant)<br />
-[[1yd6]] – BcUvrC N terminal <br />
-[[3c65]] – BstUvrC  <br />
-===UvrA-UvrB===
-[[3fpn]] – BstUvrA + UvrB <br />
-[[3uwx]] – GeUvrA + UvrB <br />
+==References==
+<references />
+</StructureSection>
 [[Category:Topic Page]]