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| [[Image:3pih.png|left|200px|thumb|Crystal structure of UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]]]
| | <StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='53/536710/Cv/3' > |
| {{STRUCTURE_3pih| PDB=3pih | SIZE=400| SCENE= |right|CAPTION= UvrA complex with DNA, pyrophosphate and Zn+2 ion [[3pih]] }}
| | == Function == |
| | '''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> |
| | * '''UvrA''' is the protein which locates the DNA damage<ref>PMID:21240268</ref>.<br /> |
| | * '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br /> |
| | * The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>. |
| | * '''UvrD''' is '''DNA helicase II'''. See [[Helicase]]. |
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| | For details on the UvrA-UvrB complex see [[UvrA-UvrB interaction domains]]. |
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| | | == Structural highlights == |
| | | UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>. |
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| '''UvrABC''' endonuclease is an E. coli enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one. For details on the UvrA-UvrB complex see [[UvrA-UvrB interaction domains]]. | |
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| ==3D structures of UvrABC== | | ==3D structures of UvrABC== |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | [[UvrABC 3D structures]] |
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| ===UvrA===
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| [[3pih]] – TmUvrA + DNA – ''Thermotoga maritima'' <br /> | |
| [[3zqj]] – UvrA – ''Mycobacterium tuberculosis''<br />
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| [[4dfc]] – EcUvrA + Transcription-repair-coupling factor – ''Escherichia coli'' <br />
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| [[2r6f]] – BstUvrA – ''Bacillus stearothermophilus'' <br />
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| [[3ux8]] – GeUvrA - ''Geobacillus''<br />
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| ===UvrB===
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| [[1d2m]], [[1c4o]] – UvrB – ''Thermus thermophilus'' <br />
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| [[1d9x]] – BcUvrB – ''Bacillus caldotenax'' <br />
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| [[1t5l]] – BcUvrB (mutant) <br />
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| [[1qoj]] – EcUvrB C terminal <br />
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| [[1e52]] – EcUvrB C terminal - NMR<br />
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| [[1d9z]] – BcUvrB + ATP <br />
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| [[2fdc]] – BcUvrB + DNA <br />
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| [[2d7d]], [[2nmv]], [[3v4r]] – BsUvrB + DNA – ''Bacillus subtilis'' <br />
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| ===UvrC===
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| [[1kft]] – EcUvrC C terminal <br />
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| [[2nrr]], [[2nrt]], [[2nrv]], [[2nrw]], [[2nrx]], [[2nrz]] – TmUvrC C terminal <br />
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| [[1ycz]], [[1yd0]], [[1yd1]] – TmUvrC N terminal <br />
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| [[1yd2]], [[1yd3]], [[1yd4]], [[1yd5]] – TmUvrC N terminal (mutant)<br />
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| [[1yd6]] – BcUvrC N terminal <br />
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| [[3c65]] – BstUvrC <br />
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| ===UvrA-UvrB===
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| [[3fpn]] – BstUvrA + UvrB <br />
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| [[3uwx]] – GeUvrA + UvrB <br />
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| | ==References== |
| | <references /> |
| | </StructureSection> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |