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UV excision repair protein: Difference between revisions

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== Function ==
== Function ==


'''UV excision repair protein''' (Rad23) is a yeast protein involved in nucleotide excision repair.  The human homologs are '''hHR23A''' and '''hHR23B'''. hHR23A plays a role in translocating polyubiquitinated proteins to the proteasome.
'''UV excision repair protein''' ('''Rad23''') is a yeast protein involved in nucleotide excision repair.  The human homologs are '''hHR23A''' and '''hHR23B'''. hHR23A plays a role in translocating polyubiquitinated proteins to the proteasome.


== Structural highlights ==
== Structural highlights ==
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The protein contains a modular domain structure consisting of ubiquitin-like domain, ubiquitin-associated domain and XPC (xeroderma pigmentosum group C protein)-binding domain<ref>PMID:21047872</ref>.
The protein contains a modular domain structure consisting of ubiquitin-like domain, ubiquitin-associated domain and XPC (xeroderma pigmentosum group C protein)-binding domain<ref>PMID:21047872</ref>.


</StructureSection>
== 3D Structures of UV excision repair protein ==
== 3D Structures of UV excision repair protein ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[UV excision repair protein 3D structures]]
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Rad23; Domains - UBL 1-78; XPC-binding 239-398
 
**[[2nbu]] – yRad23 UBL domain – yeast - NMR<br />
**[[2qsf]] – yRad23 XPC-binding domain + Rad4 <br />
**[[2qsg]], [[2qsh]], [[4yir]], [[6cfi]], [[6ubf]], [[6uin]] – yRad23 XPC-binding domain + Rad4 + DNA <br />
**[[1x3w]], [[3esw]] – yRad23 XPC-binding domain + peptide:N-glycanase<br />
**[[1x3z]] – yRad23 XPC-binding domain + peptide:N-glycanase + peptide<br />
**[[2nbw]] – yRad23 UBL domain + RPN1 - NMR<br />
**[[3m62]] – yRad23 UBL domain + Ufd2 <br />


*Rad23 homolog hHR23 A; Domains: UBA 156-204; XPC-binding 223-317
**[[1oqy]], [[1qze]] – hHR23A – human - NMR<br />
**[[1f4i]] – hHR23A C-terminal domain (mutant) - NMR<br />
**[[1ify]] – hHR23A internal UBA domain - NMR<br />
**[[5xbo]] – hHR23A internal UBA domain + ubiquitin - NMR<br />
**[[1p98]], [[2wyq]] – hHR23A UBA domain - NMR<br />
**[[1p9d]] – hHR23A UBA domain + S5a - NMR<br />
**[[1tp4]] – hHR23A XPC-binding domain - NMR<br />
*Rad23 homolog hHR23 B
**[[1p1a]] – hHR23B UBA domain - NMR<br />
**[[1pve]] – hHR23B XPC-binding domain - NMR<br />
**[[1uel]] – hHR23B UBA domain + S5a - NMR<br />
**[[1x3w]], [[2f4m]] – HR23B XPC-binding domain + peptide:N-glycanase - mouse<br />
}}
== References ==
== References ==
<references/>
<references/>
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky
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