4h12: Difference between revisions
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==The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine== | |||
<StructureSection load='4h12' size='340' side='right'caption='[[4h12]], [[Resolution|resolution]] 2.06Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4h12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3h6l 3h6l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H12 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h12 OCA], [https://pdbe.org/4h12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h12 RCSB], [https://www.ebi.ac.uk/pdbsum/4h12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h12 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SETD2_HUMAN SETD2_HUMAN] Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.<ref>PMID:16118227</ref> | |||
== | ==See Also== | ||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Amaya | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Amaya MF]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Bunnage | [[Category: Bountra C]] | ||
[[Category: Dong | [[Category: Bunnage M]] | ||
[[Category: Edwards | [[Category: Dong A]] | ||
[[Category: Mackenzie | [[Category: Edwards AM]] | ||
[[Category: Min | [[Category: Mackenzie F]] | ||
[[Category: Min J]] | |||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Wu | [[Category: Wu H]] | ||
[[Category: Zeng | [[Category: Zeng H]] | ||