4gu5: Difference between revisions

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-[[Image:4gu5.jpg|left|200px]]
-{{STRUCTURE_4gu5|  PDB=4gu5  |  SCENE=  }}
+==Structure of Full-length Drosophila Cryptochrome==
+<StructureSection load='4gu5' size='340' side='right'caption='[[4gu5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4gu5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3tvs 3tvs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GU5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu5 OCA], [https://pdbe.org/4gu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gu5 RCSB], [https://www.ebi.ac.uk/pdbsum/4gu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CRY1_DROME CRY1_DROME] Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.<ref>PMID:9845369</ref> <ref>PMID:10063806</ref> <ref>PMID:9845370</ref> <ref>PMID:10233998</ref> <ref>PMID:10417378</ref> <ref>PMID:16527739</ref> <ref>PMID:17298948</ref> <ref>PMID:18641630</ref> <ref>PMID:18597555</ref>
-===Structure of Full-length Drosophila Cryptochrome===
+==See Also==
+*[[Cryptochrome 3D structures|Cryptochrome 3D structures]]
-{{ABSTRACT_PUBMED_22080955}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[4gu5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3tvs 3tvs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU5 OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:022080955</ref><references group="xtra"/>
 [[Category: Drosophila melanogaster]]
-[[Category: Crane, B R.]]
+[[Category: Large Structures]]
-[[Category: Jones, A R.]]
+[[Category: Crane BR]]
-[[Category: Levy, C.]]
+[[Category: Jones AR]]
-[[Category: Leys, D.]]
+[[Category: Levy C]]
-[[Category: Scrutton, N S.]]
+[[Category: Leys D]]
-[[Category: Top, D.]]
+[[Category: Scrutton NS]]
-[[Category: Vaidya, A T.]]
+[[Category: Top D]]
-[[Category: Widom, J.]]
+[[Category: Vaidya AT]]
-[[Category: Young, M W.]]
+[[Category: Widom J]]
-[[Category: Zoltowski, B D.]]
+[[Category: Young MW]]
-[[Category: Circadian clock light entrainment]]
+[[Category: Zoltowski BD]]
-[[Category: Gene regulation]]
-[[Category: Jetlag]]
-[[Category: Phosphorylation]]
-[[Category: Photolyase]]
-[[Category: Protein degradation]]
-[[Category: Signaling protein]]
-[[Category: Timeless]]