4gd7: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GD7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GD7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TIY:2,3,4,6-TETRAHYDROXY-5H-BENZO[7]ANNULEN-5-ONE'>TIY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TIY:2,3,4,6-TETRAHYDROXY-5H-BENZO[7]ANNULEN-5-ONE'>TIY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gd7 OCA], [https://pdbe.org/4gd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gd7 RCSB], [https://www.ebi.ac.uk/pdbsum/4gd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gd7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gd7 OCA], [https://pdbe.org/4gd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gd7 RCSB], [https://www.ebi.ac.uk/pdbsum/4gd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gd7 ProSAT]</span></td></tr>
</table>
</table>

Latest revision as of 18:43, 14 March 2024

Wild-Type Human Thymidylate Synthase with bound PurpurogallinWild-Type Human Thymidylate Synthase with bound Purpurogallin

Structural highlights

4gd7 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.29Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYSY_HUMAN Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.[1]

See Also

References

  1. ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108

4gd7, resolution 2.29Å

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