4fyd: Difference between revisions

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New page: '''Unreleased structure''' The entry 4fyd is ON HOLD Authors: Perera, R.L., Pellegrini, L. Description: Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTP
 
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'''Unreleased structure'''


The entry 4fyd is ON HOLD
==Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTP==
<StructureSection load='4fyd' size='340' side='right'caption='[[4fyd]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fyd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FYD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fyd OCA], [https://pdbe.org/4fyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fyd RCSB], [https://www.ebi.ac.uk/pdbsum/4fyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fyd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPOLA_YEAST DPOLA_YEAST] Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase (PubMed:10898792, PubMed:22119860, PubMed:31488849). POL1 has a role in promoting telomere replication during interaction with CDC13 (PubMed:10898792).<ref>PMID:10898792</ref> <ref>PMID:22119860</ref> <ref>PMID:31488849</ref>


Authors: Perera, R.L., Pellegrini, L.
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
Description: Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTP
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Pellegrini L]]
[[Category: Perera RL]]

Latest revision as of 18:36, 14 March 2024

Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTPCrystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTP

Structural highlights

4fyd is a 6 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPOLA_YEAST Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase (PubMed:10898792, PubMed:22119860, PubMed:31488849). POL1 has a role in promoting telomere replication during interaction with CDC13 (PubMed:10898792).[1] [2] [3]

See Also

References

  1. ↑ Qi H, Zakian VA. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes Dev. 2000 Jul 15;14(14):1777-88. PMID:10898792
  2. ↑ Netz DJ, Stith CM, Stumpfig M, Kopf G, Vogel D, Genau HM, Stodola JL, Lill R, Burgers PM, Pierik AJ. Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes. Nat Chem Biol. 2011 Nov 27;8(1):125-32. doi: 10.1038/nchembio.721. PMID:22119860 doi:http://dx.doi.org/10.1038/nchembio.721
  3. ↑ Zhou ZX, Lujan SA, Burkholder AB, Garbacz MA, Kunkel TA. Roles for DNA polymerase delta in initiating and terminating leading strand DNA replication. Nat Commun. 2019 Sep 5;10(1):3992. doi: 10.1038/s41467-019-11995-z. PMID:31488849 doi:http://dx.doi.org/10.1038/s41467-019-11995-z

4fyd, resolution 3.10Å

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