4fxo: Difference between revisions

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-'''Unreleased structure'''
-The entry 4fxo is ON HOLD  until Paper Publication
+==Zinc-mediated allosteric inhibiton of caspase-6==
+<StructureSection load='4fxo' size='340' side='right'caption='[[4fxo]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4fxo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxo OCA], [https://pdbe.org/4fxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxo RCSB], [https://www.ebi.ac.uk/pdbsum/4fxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
-Authors: Velazquez-Delgado, E.M., Hardy, J.A.
+==See Also==
+*[[Caspase 3D structures|Caspase 3D structures]]
-Description: Zinc-mediated allosteric inhibiton of caspase-6
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Hardy JA]]
+[[Category: Velazquez-Delgado EM]]