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| ==KdgM porin== | | ==KdgM porin== |
| <StructureSection load='4fqe' size='340' side='right' caption='[[4fqe]], [[Resolution|resolution]] 1.93Å' scene=''> | | <StructureSection load='4fqe' size='340' side='right'caption='[[4fqe]], [[Resolution|resolution]] 1.93Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[4fqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicd3 Dicd3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQE FirstGlance]. <br> | | <table><tr><td colspan='2'>[[4fqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_dadantii_3937 Dickeya dadantii 3937]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQE FirstGlance]. <br> |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93Å</td></tr> |
| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pr7|4pr7]]</td></tr> | | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene></td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kdgM, Dda3937_03362 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198628 DICD3])</td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqe OCA], [https://pdbe.org/4fqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqe RCSB], [https://www.ebi.ac.uk/pdbsum/4fqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqe ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqe OCA], [http://pdbe.org/4fqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fqe RCSB], [http://www.ebi.ac.uk/pdbsum/4fqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqe ProSAT]</span></td></tr> | |
| </table> | | </table> |
| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/KDGM_DICD3 KDGM_DICD3]] Porin specific for oligogalacturonides. Also required for full virulence. | | [https://www.uniprot.org/uniprot/KDGM_DICD3 KDGM_DICD3] Porin specific for oligogalacturonides. Also required for full virulence. |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| The phytopathogenic Gram-negative bacterium Dickeya dadantii (Erwinia chrysanthemi) feeds on plant cell walls by secreting pectinases and utilizing the oligogalacturanate products. An outer membrane porin, KdgM, is indispensable for the uptake of these acidic oligosaccharides. Here, the crystal structure of KdgM determined to 1.9 A resolution is presented. KdgM is folded into a regular 12-stranded antiparallel beta-barrel with a circular cross-section defining a transmembrane pore with a minimal radius of 3.1 A. Most of the loops that would face the cell exterior in vivo are disordered, but nevertheless mediate contact between densely packed membrane-like layers in the crystal. The channel is lined by two tracks of arginine residues facing each other across the pore, a feature that is conserved within the KdgM family and is likely to facilitate the diffusion of acidic oligosaccharides.
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| Structure of the oligogalacturonate-specific KdgM porin.,Hutter CA, Lehner R, Wirth Ch, Condemine G, Peneff C, Schirmer T Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1770-8. doi:, 10.1107/S1399004714007147. Epub 2014 May 30. PMID:24914987<ref>PMID:24914987</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 4fqe" style="background-color:#fffaf0;"></div>
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| ==See Also== | | ==See Also== |
| *[[Porin|Porin]] | | *[[Porin 3D structures|Porin 3D structures]] |
| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Dicd3]] | | [[Category: Dickeya dadantii 3937]] |
| [[Category: Hutter, C]] | | [[Category: Large Structures]] |
| [[Category: Peneff, C M]] | | [[Category: Hutter C]] |
| [[Category: Schirmer, T]] | | [[Category: Peneff CM]] |
| [[Category: Wirth, C]] | | [[Category: Schirmer T]] |
| [[Category: Beta barrel]] | | [[Category: Wirth C]] |
| [[Category: Membrane protein]]
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| [[Category: Oligogalacturonate specificity]]
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| [[Category: Outer membrane protein]]
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| [[Category: Porin]]
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