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==Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed== | ==Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed== | ||
<StructureSection load='4fox' size='340' side='right' caption='[[4fox]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4fox' size='340' side='right'caption='[[4fox]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4fox]] is a 8 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4fox]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FOX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D16:TOMUDEX'>D16</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fox OCA], [https://pdbe.org/4fox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fox RCSB], [https://www.ebi.ac.uk/pdbsum/4fox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fox ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity). | ||
==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Bruning | [[Category: Bruning JB]] | ||
[[Category: Harshbarger | [[Category: Harshbarger W]] | ||
[[Category: Reddy | [[Category: Reddy MCM]] | ||
[[Category: Sacchettini | [[Category: Sacchettini JC]] | ||
Latest revision as of 18:30, 14 March 2024
Crystal Structure of Mtb ThyA in complex with dUMP and RaltitrexedCrystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed
Structural highlights
FunctionTYSY_MYCTU Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity). See Also |
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