4fnh: Difference between revisions
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==Crystal structure of IsdI-W66Y in complex with heme== | |||
<StructureSection load='4fnh' size='340' side='right'caption='[[4fnh]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4fnh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FNH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fnh OCA], [https://pdbe.org/4fnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fnh RCSB], [https://www.ebi.ac.uk/pdbsum/4fnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fnh ProSAT]</span></td></tr> | ||
[[4fnh]] is a 2 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HDOX2_STAAN HDOX2_STAAN] Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.[HAMAP-Rule:MF_01272]<ref>PMID:18713745</ref> <ref>PMID:20180905</ref> | |||
==See Also== | ==See Also== | ||
*[[Heme oxygenase|Heme oxygenase]] | *[[Heme oxygenase 3D structures|Heme oxygenase 3D structures]] | ||
[[Category: | *[[Monooxygenase 3D structures|Monooxygenase 3D structures]] | ||
[[Category: Staphylococcus aureus subsp. aureus | == References == | ||
[[Category: Murphy | <references/> | ||
[[Category: Ukpabi | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus subsp. aureus N315]] | |||
[[Category: Murphy MEP]] | |||
[[Category: Ukpabi GN]] | |||
Latest revision as of 18:30, 14 March 2024
Crystal structure of IsdI-W66Y in complex with hemeCrystal structure of IsdI-W66Y in complex with heme
Structural highlights
FunctionHDOX2_STAAN Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.[HAMAP-Rule:MF_01272][1] [2] See AlsoReferences
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