4fmu: Difference between revisions

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-'''Unreleased structure'''
-The entry 4fmu is ON HOLD
+==Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF==
+<StructureSection load='4fmu' size='340' side='right'caption='[[4fmu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4fmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FMU FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0UM:(2S,5S)-2-AMINO-6-[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]-5-(PROPYLAMINO)HEXANOIC+ACID'>0UM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmu OCA], [https://pdbe.org/4fmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fmu RCSB], [https://www.ebi.ac.uk/pdbsum/4fmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SETD2_HUMAN SETD2_HUMAN] Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.<ref>PMID:16118227</ref>
-Authors: Dong, A., Zeng, H., Ibez, G., Zheng, W., Tempel, W., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-Description: Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith CH]]
+[[Category: Bountra C]]
+[[Category: Brown PJ]]
+[[Category: Dong A]]
+[[Category: Edwards AM]]
+[[Category: Ibanez G]]
+[[Category: Luo M]]
+[[Category: Min J]]
+[[Category: Tempel W]]
+[[Category: Wu H]]
+[[Category: Zeng H]]
+[[Category: Zheng W]]