4fev: Difference between revisions

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[[Image:4fev.png|left|200px]]


{{STRUCTURE_4fev| PDB=4fev | SCENE= }}
==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1==
<StructureSection load='4fev' size='340' side='right'caption='[[4fev]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fev]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PP1:1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fev OCA], [https://pdbe.org/4fev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fev RCSB], [https://www.ebi.ac.uk/pdbsum/4fev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fev ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B0VD92_ACIBY B0VD92_ACIBY]


===Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1===
==See Also==
 
*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4fev]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEV OCA].
[[Category: Acinetobacter baumannii AYE]]
[[Category: Acinetobacter baumannii]]
[[Category: Large Structures]]
[[Category: Kanamycin kinase]]
[[Category: Anderson WF]]
[[Category: Anderson, W F.]]
[[Category: Di Leo R]]
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
[[Category: Egorova O]]
[[Category: Egorova, O.]]
[[Category: Evdokimova E]]
[[Category: Evdokimova, E.]]
[[Category: Minasov G]]
[[Category: Leo, R Di.]]
[[Category: Savchenko A]]
[[Category: Minasov, G.]]
[[Category: Shakya T]]
[[Category: Savchenko, A.]]
[[Category: Spanogiannopoulos P]]
[[Category: Shakya, T.]]
[[Category: Stogios PJ]]
[[Category: Spanogiannopoulos, P.]]
[[Category: Wawrzak Z]]
[[Category: Stogios, P J.]]
[[Category: Wright GD]]
[[Category: Wawrzak, Z.]]
[[Category: Wright, G D.]]
[[Category: Alpha/beta protein]]
[[Category: Aminoglycoside phosphotransferase]]
[[Category: Aminoglycoside]]
[[Category: Antibiotic resistance]]
[[Category: Center for structural genomics of infectious disease]]
[[Category: Csgid]]
[[Category: Eukaryotic protein kinase-like fold]]
[[Category: Gtp]]
[[Category: Intracellular]]
[[Category: Kanamycin]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Phosphotransferase]]
[[Category: Pp1]]
[[Category: Protein kinase inhibitor]]
[[Category: Pyrazolopyrimidine]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]

Latest revision as of 18:23, 14 March 2024

Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1

Structural highlights

4fev is a 6 chain structure with sequence from Acinetobacter baumannii AYE. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.89Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

B0VD92_ACIBY

See Also

4fev, resolution 1.89Å

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