4fea: Difference between revisions

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-'''Unreleased structure'''
-The entry 4fea is ON HOLD
+==Crystal structure of CASPASE-7 in Complex with allosteric inhibitor==
+<StructureSection load='4fea' size='340' side='right'caption='[[4fea]], [[Resolution|resolution]] 3.79&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4fea]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEA FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.79&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TE:CHLORO{METHYL+HYDROGENATO(3-)-KAPPA~2~N,S+[PYRIDIN-2-YL(PYRIDIN-2(1H)-YLIDENE-KAPPAN)METHYL]CARBONODITHIOHYDRAZONATE}COPPER'>0TE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fea OCA], [https://pdbe.org/4fea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fea RCSB], [https://www.ebi.ac.uk/pdbsum/4fea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fea ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
-Authors: Feldman, T., Kabaleeswaran, V., Jang, S.B., Antczak, C., Djaballah, H., Wu, H., Jiang, X.
+==See Also==
+*[[Caspase 3D structures|Caspase 3D structures]]
-Description: Crystal structure of CASPASE-7 in Complex with allosteric inhibitor
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kabaleeswaran V]]