4fcp: Difference between revisions

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-'''Unreleased structure'''
-The entry 4fcp is ON HOLD
+==Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization==
+<StructureSection load='4fcp' size='340' side='right'caption='[[4fcp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4fcp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCP FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42C:N,N-DIMETHYL-7H-PURIN-6-AMINE'>42C</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcp OCA], [https://pdbe.org/4fcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcp RCSB], [https://www.ebi.ac.uk/pdbsum/4fcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
-Authors: Davies, N.G.M., Browne, H., Davies, B., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Drysdale, M., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Roughley, S.D., Jensen, M.R., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wright, L., Brough, P.
+==See Also==
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
-Description: Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Brough P]]
+[[Category: Browne H]]
+[[Category: Davies B]]
+[[Category: Davies NGM]]
+[[Category: Drysdale M]]
+[[Category: Foloppe N]]
+[[Category: Geoffrey S]]
+[[Category: Gibbons B]]
+[[Category: Hart T]]
+[[Category: Jensen MR]]
+[[Category: Mansell H]]
+[[Category: Massey A]]
+[[Category: Matassova N]]
+[[Category: Moore JD]]
+[[Category: Murray J]]
+[[Category: Pratt R]]
+[[Category: Ray S]]
+[[Category: Roughley SD]]
+[[Category: Schoepfer J]]
+[[Category: Scriven K]]
+[[Category: Simmonite H]]
+[[Category: Stokes S]]
+[[Category: Surgenor A]]
+[[Category: Webb P]]
+[[Category: Wright L]]