4f99: Difference between revisions

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'''Unreleased structure'''


The entry 4f99 is ON HOLD  until Paper Publication
==Human CDC7 kinase in complex with DBF4 and nucleotide==
 
<StructureSection load='4f99' size='340' side='right'caption='[[4f99]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
Authors: Hughes, S., Cherepanov, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4f99]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F99 FirstGlance]. <br>
Description: Human CDC7 kinase in complex with DBF4 and nucleotide
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f99 OCA], [https://pdbe.org/4f99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f99 RCSB], [https://www.ebi.ac.uk/pdbsum/4f99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f99 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDC7_HUMAN CDC7_HUMAN] Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.<ref>PMID:12065429</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cherepanov P]]
[[Category: Hughes S]]

Latest revision as of 18:19, 14 March 2024

Human CDC7 kinase in complex with DBF4 and nucleotideHuman CDC7 kinase in complex with DBF4 and nucleotide

Structural highlights

4f99 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.33Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CDC7_HUMAN Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.[1]

References

  1. ↑ Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C. Drf1, a novel regulatory subunit for human Cdc7 kinase. EMBO J. 2002 Jun 17;21(12):3171-81. PMID:12065429 doi:http://dx.doi.org/10.1093/emboj/cdf290

4f99, resolution 2.33Å

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