4eki: Difference between revisions

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[[Image:4eki.png|left|200px]]


{{STRUCTURE_4eki| PDB=4eki | SCENE= }}  
==Crystal Structure of DOT1L in complex with EPZ004777==
<StructureSection load='4eki' size='340' side='right'caption='[[4eki]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4eki]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EKI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eki OCA], [https://pdbe.org/4eki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eki RCSB], [https://www.ebi.ac.uk/pdbsum/4eki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eki ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.


===Crystal Structure of DOT1L in complex with EPZ004777===
==See Also==
 
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
{{ABSTRACT_PUBMED_22978415}}
__TOC__
 
</StructureSection>
==About this Structure==
[[4eki]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKI OCA].
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Jin, L.]]
[[Category: Large Structures]]
[[Category: Methyltransferase]]
[[Category: Jin L]]
[[Category: Transferase-transferase inhibitor complex]]

Latest revision as of 18:03, 14 March 2024

Crystal Structure of DOT1L in complex with EPZ004777Crystal Structure of DOT1L in complex with EPZ004777

Structural highlights

4eki is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.85Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DOT1L_HUMAN Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

See Also

4eki, resolution 2.85Å

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