4eki: Difference between revisions

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-[[Image:4eki.jpg|left|200px]]
-{{STRUCTURE_4eki|  PDB=4eki  |  SCENE=  }}
+==Crystal Structure of DOT1L in complex with EPZ004777==
+<StructureSection load='4eki' size='340' side='right'caption='[[4eki]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4eki]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EKI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eki OCA], [https://pdbe.org/4eki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eki RCSB], [https://www.ebi.ac.uk/pdbsum/4eki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eki ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
-===Crystal Structure of DOT1L in complex with EPZ004777===
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-{{ABSTRACT_PUBMED_22978415}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4eki]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKI OCA].
-[[Category: Histone-lysine N-methyltransferase]]
 [[Category: Homo sapiens]]
-[[Category: Jin, L.]]
+[[Category: Large Structures]]
-[[Category: Methyltransferase]]
+[[Category: Jin L]]
-[[Category: Transferase-transferase inhibitor complex]]