4ek9: Difference between revisions

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-[[Image:4ek9.png|left|200px]]
-{{STRUCTURE_4ek9|  PDB=4ek9  |  SCENE=  }}
+==Crystal structure of DOT1L in complex with EPZ000004==
+<StructureSection load='4ek9' size='340' side='right'caption='[[4ek9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ek9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EK9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EP4:5-DEOXY-5-(DIMETHYLAMINO)ADENOSINE'>EP4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ek9 OCA], [https://pdbe.org/4ek9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ek9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ek9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ek9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
-===Crystal structure of DOT1L in complex with EPZ000004===
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-{{ABSTRACT_PUBMED_22978415}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EK9 OCA].
-[[Category: Histone-lysine N-methyltransferase]]
 [[Category: Homo sapiens]]
-[[Category: Jin, L.]]
+[[Category: Large Structures]]
-[[Category: Methyltransferase]]
+[[Category: Jin L]]
-[[Category: Transferase]]
-[[Category: Transferase-transferase inhibitor complex]]