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{{STRUCTURE_4e96|  PDB=4e96  |  SCENE=  }}
===Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1===
{{ABSTRACT_PUBMED_23095041}}


==Disease==
==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>  
<StructureSection load='4e96' size='340' side='right'caption='[[4e96]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4e96]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E96 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NS:2-METHOXY-N-(3-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINAZOLIN-6-YL)BENZENESULFONAMIDE'>0NS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e96 OCA], [https://pdbe.org/4e96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e96 RCSB], [https://www.ebi.ac.uk/pdbsum/4e96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e96 ProSAT]</span></td></tr>
[[4e96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E96 OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>  
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


==See Also==
==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
*[[Multiple sclerosis|Multiple sclerosis]]
*[[Multiple sclerosis|Multiple sclerosis]]
 
== References ==
==Reference==
<references/>
<references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bunnage, M.]]
[[Category: Arrowsmith CH]]
[[Category: Cook, A.]]
[[Category: Bunnage M]]
[[Category: Delft, F von.]]
[[Category: Cook A]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Fedorov, O.]]
[[Category: Fedorov O]]
[[Category: Felletar, I.]]
[[Category: Felletar I]]
[[Category: Filippakopoulos, P.]]
[[Category: Filippakopoulos P]]
[[Category: Fish, P.]]
[[Category: Fish P]]
[[Category: Knapp, S.]]
[[Category: Knapp S]]
[[Category: Owen, D.]]
[[Category: Owen D]]
[[Category: Picaud, S.]]
[[Category: Picaud S]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Betsoff1]]
[[Category: Bromodomain]]
[[Category: Cap]]
[[Category: Cell cycle]]
[[Category: Hunk1]]
[[Category: Jq1]]
[[Category: Mcap]]
[[Category: Mitotic chromosome associated protein]]
[[Category: Protein binding-inhibitor complex]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]

Latest revision as of 17:55, 14 March 2024

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1

Structural highlights

4e96 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.92Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

BRD4_HUMAN Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

BRD4_HUMAN Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

See Also

References

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

4e96, resolution 1.92Å

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