4e86: Difference between revisions

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{{STRUCTURE_4e86|  PDB=4e86  |  SCENE=  }}
===Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)===
{{ABSTRACT_PUBMED_22573326}}


==Function==
==Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)==
[[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>
<StructureSection load='4e86' size='340' side='right'caption='[[4e86]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4e86]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E86 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e86 OCA], [https://pdbe.org/4e86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e86 RCSB], [https://www.ebi.ac.uk/pdbsum/4e86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e86 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>  


==About this Structure==
==See Also==
[[4e86]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E86 OCA].
*[[Defensin 3D structures|Defensin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022573326</ref><references group="xtra"/><references/>
__TOC__
[[Category: Pazgier, M.]]
</StructureSection>
[[Category: Wu, X.]]
[[Category: Homo sapiens]]
[[Category: Antimicrobial peptide]]
[[Category: Large Structures]]
[[Category: Antimicrobial protein]]
[[Category: Pazgier M]]
[[Category: Beta-sheet]]
[[Category: Wu X]]
[[Category: Mutant leu29aba]]
[[Category: Paneth cell]]

Latest revision as of 17:55, 14 March 2024

Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)

Structural highlights

4e86 is a 9 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.75Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DEF5_HUMAN Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.[1] [2] [3]

See Also

References

  1. ↑ Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun;3(6):583-90. Epub 2002 May 20. PMID:12021776 doi:10.1038/ni797
  2. ↑ Ericksen B, Wu Z, Lu W, Lehrer RI. Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-75. PMID:15616305 doi:10.1128/AAC.49.1.269-275.2005
  3. ↑ Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J. Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci. 2006 Dec;15(12):2749-60. Epub 2006 Nov 6. PMID:17088326 doi:ps.062336606

4e86, resolution 2.75Å

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