4drv: Difference between revisions

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-'''Unreleased structure'''
-The entry 4drv is ON HOLD
+==Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen==
+<StructureSection load='4drv' size='340' side='right'caption='[[4drv]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4drv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRV FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drv OCA], [https://pdbe.org/4drv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drv RCSB], [https://www.ebi.ac.uk/pdbsum/4drv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q86169_9REOV Q86169_9REOV] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874]  VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]
-Authors: Prasad, B.V.V., Hu, L., Crawford, S.E., Cortes-Penfield, N.W., Smith, D.F., Le Pendu, J., Estes, M.K.
+==See Also==
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-Description: Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rotavirus sp]]
+[[Category: Cortes-Penfield NW]]
+[[Category: Crawford SE]]
+[[Category: Czako R]]
+[[Category: Estes MK]]
+[[Category: Hu L]]
+[[Category: Le Pendu J]]
+[[Category: Prasad BVV]]
+[[Category: Smith DF]]