4dbs: Difference between revisions

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-[[Image:4dbs.png|left|200px]]
-{{STRUCTURE_4dbs|  PDB=4dbs  |  SCENE=  }}
+==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid==
+<StructureSection load='4dbs' size='340' side='right'caption='[[4dbs]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4dbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DBS FirstGlance]. <br>
-{{ABSTRACT_PUBMED_22507964}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.852&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HV:3-[(4-NITRONAPHTHALEN-1-YL)AMINO]BENZOIC+ACID'>0HV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbs OCA], [https://pdbe.org/4dbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dbs RCSB], [https://www.ebi.ac.uk/pdbsum/4dbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbs ProSAT]</span></td></tr>
-[[4dbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBS OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
 ==See Also==
-*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
+*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:022507964</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Chen, M.]]
+[[Category: Large Structures]]
-[[Category: Christianson, D W.]]
+[[Category: Chen M]]
-[[Category: Penning, T M.]]
+[[Category: Christianson DW]]
-[[Category: Winkler, J D.]]
+[[Category: Penning TM]]
-[[Category: Akr1c3 selective inhibitor]]
+[[Category: Winkler JD]]
-[[Category: Castrate resistant prostate cancer]]
-[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
-[[Category: Steroid metabolism]]
-[[Category: Tim barrel]]