3v1g: Difference between revisions

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-[[Image:3v1g.jpg|left|200px]]
-{{STRUCTURE_3v1g|  PDB=3v1g  |  SCENE=  }}
+==Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health==
+<StructureSection load='3v1g' size='340' side='right'caption='[[3v1g]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3v1g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V1G FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v1g OCA], [https://pdbe.org/3v1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v1g RCSB], [https://www.ebi.ac.uk/pdbsum/3v1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v1g ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[https://omim.org/entry/176730 176730].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref>   Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[https://omim.org/entry/125852 125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref>   Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[https://omim.org/entry/606176 606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref>   Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[https://omim.org/entry/613370 613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
-===Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health===
+==See Also==
+*[[Insulin 3D Structures|Insulin 3D Structures]]
+== References ==
-==About this Structure==
+<references/>
-[[3v1g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1G OCA].
+__TOC__
-[[Category: Hu, S Q.]]
+</StructureSection>
-[[Category: Hua, Q X.]]
+[[Category: Homo sapiens]]
-[[Category: Huang, K.]]
+[[Category: Large Structures]]
-[[Category: Ismail-Beigi, F.]]
+[[Category: Hu SQ]]
-[[Category: Katsoyyannis, P G.]]
+[[Category: Hua QX]]
-[[Category: Petkova, A T.]]
+[[Category: Huang K]]
-[[Category: Phillips, N B.]]
+[[Category: Ismail-Beigi F]]
-[[Category: Tycko, R.]]
+[[Category: Katsoyyannis PG]]
-[[Category: Wan, Z L.]]
+[[Category: Petkova AT]]
-[[Category: Weiss, M A.]]
+[[Category: Phillips NB]]
-[[Category: Whittake, J.]]
+[[Category: Tycko R]]
-[[Category: Wickramasinghe, N P.]]
+[[Category: Wan ZL]]
-[[Category: Yeh, I J.]]
+[[Category: Weiss MA]]
-[[Category: Hormone]]
+[[Category: Whittake J]]
-[[Category: Insulin fibrillation]]
+[[Category: Wickramasinghe NP]]
-[[Category: Long-acting insulin analog]]
+[[Category: Yeh IJ]]
-[[Category: Receptor binding protein engineering]]
-[[Category: Zinc-binding site]]