3v0n: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 3v0n is ON HOLD
+==Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-GalNAc derived inhibitor (3GW and 4GW)==
+<StructureSection load='3v0n' size='340' side='right'caption='[[3v0n]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3v0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V0N FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3GW:5-(5-FORMYLTHIOPHEN-2-YL)URIDINE-5(2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GALACTOSYL)-DIPHOSPHATE'>3GW</scene>, <scene name='pdbligand=4GW:5-(5-FORMYLTHIOPHEN-2-YL)URIDINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>4GW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0n OCA], [https://pdbe.org/3v0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v0n RCSB], [https://www.ebi.ac.uk/pdbsum/3v0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v0n ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
-Authors: Palcic, M. M., Jorgensen, R.
+==See Also==
+*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
-Description: Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-GalNAc derived inhibitor (3GW and 4GW)
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jorgensen R]]
+[[Category: Palcic MM]]