3ut1: Difference between revisions

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==Crystal structure of the 3-MBT repeat domain of L3MBTL3==
==Crystal structure of the 3-MBT repeat domain of L3MBTL3==
<StructureSection load='3ut1' size='340' side='right' caption='[[3ut1]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='3ut1' size='340' side='right'caption='[[3ut1]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ut1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UT1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ut1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UT1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L3MBTL3, KIAA1798, MBT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ut1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ut1 OCA], [http://pdbe.org/3ut1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ut1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ut1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ut1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ut1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ut1 OCA], [https://pdbe.org/3ut1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ut1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ut1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ut1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LMBL3_HUMAN LMBL3_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).  
[https://www.uniprot.org/uniprot/LMBL3_HUMAN LMBL3_HUMAN] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Brown, P J]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Brown PJ]]
[[Category: Graslund, S]]
[[Category: Edwards AM]]
[[Category: Structural genomic]]
[[Category: Graslund S]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Wernimont, A K]]
[[Category: Wernimont AK]]
[[Category: Zhong, N]]
[[Category: Zhong N]]
[[Category: Chromatin modification]]
[[Category: Mbt repeat]]
[[Category: Sgc]]
[[Category: Transcription]]
[[Category: Transcription repression]]

Latest revision as of 17:07, 14 March 2024

Crystal structure of the 3-MBT repeat domain of L3MBTL3Crystal structure of the 3-MBT repeat domain of L3MBTL3

Structural highlights

3ut1 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LMBL3_HUMAN Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).

3ut1, resolution 2.05Å

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