3uhs: Difference between revisions

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==HBI (L36M) deoxy==
==HBI (L36M) deoxy==
<StructureSection load='3uhs' size='340' side='right' caption='[[3uhs]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3uhs' size='340' side='right'caption='[[3uhs]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uhs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UHS FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uhs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UHS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sdh|3sdh]], [[4sdh|4sdh]], [[3ugy|3ugy]], [[3ugz|3ugz]], [[3uh3|3uh3]], [[3uh5|3uh5]], [[3uh6|3uh6]], [[3uh7|3uh7]], [[3uhb|3uhb]], [[3uhc|3uhc]], [[3uhd|3uhd]], [[3uhe|3uhe]], [[3uhg|3uhg]], [[3uhh|3uhh]], [[3uhi|3uhi]], [[3uhk|3uhk]], [[3uhn|3uhn]], [[3uhq|3uhq]], [[3uhr|3uhr]], [[3uht|3uht]], [[3uhu|3uhu]], [[3uhv|3uhv]], [[3uhw|3uhw]], [[3uhx|3uhx]], [[3uhy|3uhy]], [[3uhz|3uhz]], [[3ui0|3ui0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uhs RCSB], [http://www.ebi.ac.uk/pdbsum/3uhs PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhs OCA], [https://pdbe.org/3uhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uhs RCSB], [https://www.ebi.ac.uk/pdbsum/3uhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uhs ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
Here we present a meta-analysis of a large collection of static structures of a protein in the Protein Data Bank in order to extract the progression of structural events during protein function. We apply this strategy to the homodimeric hemoglobin HbI from Scapharca inaequivalvis. We derive a simple dynamic model describing how binding of the first ligand in one of the two chemically identical subunits facilitates a second binding event in the other partner subunit. The results of our ultrafast time-resolved crystallographic studies support this model. We demonstrate that HbI functions like a homodimeric mechanical device, such as pliers or scissors. Ligand-induced motion originating in one subunit is transmitted to the other via conserved pivot points, where the E and F' helices from two partner subunits are "bolted" together to form a stable dimer interface permitting slight relative rotation but preventing sliding.
 
Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures.,Ren Z, Srajer V, Knapp JE, Royer WE Jr Proc Natl Acad Sci U S A. 2011 Dec 14. PMID:22171006<ref>PMID:22171006</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


==See Also==
==See Also==
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Scapharca inaequivalvis]]
[[Category: Anadara inaequivalvis]]
[[Category: Knapp, J E]]
[[Category: Large Structures]]
[[Category: Ren, Z]]
[[Category: Knapp JE]]
[[Category: Royer, W E]]
[[Category: Ren Z]]
[[Category: Srajer, V]]
[[Category: Royer Jr WE]]
[[Category: Allostery]]
[[Category: Srajer V]]
[[Category: Oxygen binding]]
[[Category: Oxygen storage]]
[[Category: Oxygen transport]]

Latest revision as of 16:58, 14 March 2024

HBI (L36M) deoxyHBI (L36M) deoxy

Structural highlights

3uhs is a 2 chain structure with sequence from Anadara inaequivalvis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLB1_ANAIN

See Also

3uhs, resolution 2.10Å

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