3ud1: Difference between revisions

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-[[Image:3ud1.jpg|left|200px]]
-<!--
+==Crystal structure of ZU5A-ZU5B domains of human erythrocyte ankyrin==
-The line below this paragraph, containing "STRUCTURE_3ud1", creates the "Structure Box" on the page.
+<StructureSection load='3ud1' size='340' side='right'caption='[[3ud1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ud1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UD1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr>
-{{STRUCTURE_3ud1|  PDB=3ud1  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ud1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ud1 OCA], [https://pdbe.org/3ud1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ud1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ud1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ud1 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN] Defects in ANK1 are a cause of spherocytosis type 1 (SPH1) [MIM:[https://omim.org/entry/182900 182900]; also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive.<ref>PMID:8640229</ref> <ref>PMID:11102985</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN] Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.<ref>PMID:12456646</ref>   Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:12456646</ref>
-===Crystal structure of ZU5A-ZU5B domains of human erythrocyte ankyrin===
+==See Also==
+*[[Ankyrin 3D structures|Ankyrin 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-[[3ud1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UD1 OCA].
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:022310050</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Ipsaro, J J.]]
+[[Category: Large Structures]]
-[[Category: Mondragon, A.]]
+[[Category: Ipsaro JJ]]
-[[Category: Yasunaga, M.]]
+[[Category: Mondragon A]]
-[[Category: Adapter protein]]
+[[Category: Yasunaga M]]
-[[Category: Beta sandwich]]
-[[Category: Cytoskeleton]]
-[[Category: Protein binding]]
-[[Category: Spectrin binding]]
-[[Category: Zu5]]