3u9h: Difference between revisions

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-[[Image:3u9h.png|left|200px]]
-{{STRUCTURE_3u9h|  PDB=3u9h  |  SCENE=  }}
+==Complex structure of human tankyrase 2 with nicotinamide==
+<StructureSection load='3u9h' size='340' side='right'caption='[[3u9h]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-===Complex structure of human tankyrase 2 with nicotinamide===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3u9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U9H FirstGlance]. <br>
-{{ABSTRACT_PUBMED_22233320}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u9h OCA], [https://pdbe.org/3u9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u9h RCSB], [https://www.ebi.ac.uk/pdbsum/3u9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u9h ProSAT]</span></td></tr>
-[[3u9h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9H OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
 ==See Also==
-*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
+*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:022233320</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Lehtio, L.]]
+[[Category: Large Structures]]
-[[Category: Narwal, M.]]
+[[Category: Lehtio L]]
-[[Category: Adp-ribosylation]]
+[[Category: Narwal M]]
-[[Category: Diphtheria toxin like fold]]
-[[Category: Protein-ligand complex]]
-[[Category: Transferase]]