3u7x: Difference between revisions

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-[[Image:3u7x.png|left|200px]]
-{{STRUCTURE_3u7x|  PDB=3u7x  |  SCENE=  }}
+==Crystal structure of the human eIF4E-4EBP1 peptide complex without cap==
+<StructureSection load='3u7x' size='340' side='right'caption='[[3u7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-===Crystal structure of the human eIF4E-4EBP1 peptide complex without cap===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3u7x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3smu 3smu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7X FirstGlance]. <br>
-{{ABSTRACT_PUBMED_22178476}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7x OCA], [https://pdbe.org/3u7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7x RCSB], [https://www.ebi.ac.uk/pdbsum/3u7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7x ProSAT]</span></td></tr>
-[[3u7x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3smu 3smu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7X OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
 ==See Also==
-*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
+*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:022178476</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Borden, K L.B.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C.]]
+[[Category: Borden KLB]]
-[[Category: Edwards, A M.]]
+[[Category: Bountra C]]
-[[Category: Nedyalkova, L.]]
+[[Category: Edwards AM]]
-[[Category: Park, H.]]
+[[Category: Nedyalkova L]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Park H]]
-[[Category: Siddiqui, N.]]
+[[Category: Siddiqui N]]
-[[Category: Tempel, W.]]
+[[Category: Tempel W]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Wernimont, A K.]]
+[[Category: Wernimont AK]]
-[[Category: 4ebp1]]
-[[Category: Eif4e]]
-[[Category: Mrna export]]
-[[Category: Sgc]]
-[[Category: Structural genomics consortium]]
-[[Category: Translation]]