3u5k: Difference between revisions

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[[Image:3u5k.png|left|200px]]


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==Crystal Structure of the first bromodomain of human BRD4 in complex with Midazolam==
The line below this paragraph, containing "STRUCTURE_3u5k", creates the "Structure Box" on the page.
<StructureSection load='3u5k' size='340' side='right'caption='[[3u5k]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3u5k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U5K FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=08J:8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE'>08J</scene></td></tr>
{{STRUCTURE_3u5k|  PDB=3u5k  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u5k OCA], [https://pdbe.org/3u5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u5k RCSB], [https://www.ebi.ac.uk/pdbsum/3u5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u5k ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>  
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


===Crystal Structure of the first bromodomain of human BRD4 in complex with Midazolam===
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_22137933}}
 
==About this Structure==
[[3u5k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U5K OCA].
 
==Reference==
<ref group="xtra">PMID:022137933</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F von.]]
[[Category: Bountra C]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Fedorov, O.]]
[[Category: Fedorov O]]
[[Category: Felletar, I.]]
[[Category: Felletar I]]
[[Category: Filippakopoulos, P.]]
[[Category: Filippakopoulos P]]
[[Category: Knapp, S.]]
[[Category: Knapp S]]
[[Category: Picaud, S.]]
[[Category: Picaud S]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Brd4]]
[[Category: Bromodomain containing protein 4]]
[[Category: Bromodomain-containing protein 4 isoform long]]
[[Category: Cap]]
[[Category: Hunk1]]
[[Category: Mcap]]
[[Category: Mitotic chromosome associated protein]]
[[Category: Sgc]]
[[Category: Signaling protein-inhibitor complex]]
[[Category: Structural genomics consortium]]

Latest revision as of 16:48, 14 March 2024

Crystal Structure of the first bromodomain of human BRD4 in complex with MidazolamCrystal Structure of the first bromodomain of human BRD4 in complex with Midazolam

Structural highlights

3u5k is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

BRD4_HUMAN Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

BRD4_HUMAN Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

See Also

References

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

3u5k, resolution 1.80Å

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