3tlp: Difference between revisions

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-[[Image:3tlp.jpg|left|200px]]
-<!--
+==Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1)==
-The line below this paragraph, containing "STRUCTURE_3tlp", creates the "Structure Box" on the page.
+<StructureSection load='3tlp' size='340' side='right'caption='[[3tlp]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3tlp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TLP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-{{STRUCTURE_3tlp|  PDB=3tlp  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tlp OCA], [https://pdbe.org/3tlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tlp RCSB], [https://www.ebi.ac.uk/pdbsum/3tlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tlp ProSAT]</span></td></tr>
+</table>
-===Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1)===
+== Disease ==
+[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
+== Function ==
-==About this Structure==
+[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
-[[3tlp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TLP OCA].
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Allerston, C K.]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Allerston CK]]
-[[Category: Bountra, C.]]
+[[Category: Arrowsmith CH]]
-[[Category: Delft, F von.]]
+[[Category: Bountra C]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Felletar, I.]]
+[[Category: Felletar I]]
-[[Category: Filippakopoulos, P.]]
+[[Category: Filippakopoulos P]]
-[[Category: Keates, T.]]
+[[Category: Keates T]]
-[[Category: Knapp, S.]]
+[[Category: Knapp S]]
-[[Category: Krojer, T.]]
+[[Category: Krojer T]]
-[[Category: Latwiel, S.]]
+[[Category: Latwiel S]]
-[[Category: Muniz, J.]]
+[[Category: Muniz J]]
-[[Category: Picaud, S.]]
+[[Category: Picaud S]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Von Delft F]]
-[[Category: Baf180]]
-[[Category: Brg1-associated factor 180]]
-[[Category: Bromodomain]]
-[[Category: Pb1]]
-[[Category: Pbrm1]]
-[[Category: Polybromo 1 isoform 1]]
-[[Category: Polybromo-1d]]
-[[Category: Sgc]]
-[[Category: Structural genomics consortium]]
-[[Category: Transcription]]