3tf2: Difference between revisions

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[[Image:3tf2.png|left|200px]]


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==Crystal structure of the cap free human translation initiation factor eIF4E==
The line below this paragraph, containing "STRUCTURE_3tf2", creates the "Structure Box" on the page.
<StructureSection load='3tf2' size='340' side='right'caption='[[3tf2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3tf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TF2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
{{STRUCTURE_3tf2|  PDB=3tf2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tf2 OCA], [https://pdbe.org/3tf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tf2 RCSB], [https://www.ebi.ac.uk/pdbsum/3tf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tf2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>  


===Crystal structure of the cap free human translation initiation factor eIF4E===
==See Also==
 
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_22178476}}
 
==About this Structure==
[[3tf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF2 OCA].
 
==Reference==
<ref group="xtra">PMID:022178476</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Borden, K L.B.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Borden KLB]]
[[Category: Edwards, A M.]]
[[Category: Bountra C]]
[[Category: Nedyalkova, L.]]
[[Category: Edwards AM]]
[[Category: Park, H.]]
[[Category: Nedyalkova L]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Park H]]
[[Category: Siddiqui, N.]]
[[Category: Siddiqui N]]
[[Category: Tempel, W.]]
[[Category: Tempel W]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Wernimont, A K.]]
[[Category: Wernimont AK]]
[[Category: Eif4e]]
[[Category: Mrna export]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Translation]]

Latest revision as of 16:26, 14 March 2024

Crystal structure of the cap free human translation initiation factor eIF4ECrystal structure of the cap free human translation initiation factor eIF4E

Structural highlights

3tf2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IF4E_HUMAN Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.[1]

See Also

References

  1. ↑ Tomoo K, Matsushita Y, Fujisaki H, Abiko F, Shen X, Taniguchi T, Miyagawa H, Kitamura K, Miura K, Ishida T. Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. Biochim Biophys Acta. 2005 Dec 1;1753(2):191-208. Epub 2005 Aug 24. PMID:16271312 doi:10.1016/j.bbapap.2005.07.023

3tf2, resolution 2.10Å

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