3t0f: Difference between revisions

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-[[Image:3t0f.png|left|200px]]
-<!--
+==IspH:HMBPP (substrate) structure of the E126D mutant==
-The line below this paragraph, containing "STRUCTURE_3t0f", creates the "Structure Box" on the page.
+<StructureSection load='3t0f' size='340' side='right'caption='[[3t0f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3t0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T0F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene></td></tr>
-{{STRUCTURE_3t0f|  PDB=3t0f  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t0f OCA], [https://pdbe.org/3t0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t0f RCSB], [https://www.ebi.ac.uk/pdbsum/3t0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t0f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
-===IspH:HMBPP (substrate) structure of the E126D mutant===
+==See Also==
+*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_22137895}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 22137895 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Escherichia coli K-12]]
-{{ABSTRACT_PUBMED_22137895}}
+[[Category: Large Structures]]
+[[Category: Bacher A]]
-==About this Structure==
+[[Category: Eisenreich W]]
-[[3t0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0F OCA].
+[[Category: Graewert T]]
+[[Category: Groll M]]
-==Reference==
+[[Category: Span I]]
-<ref group="xtra">PMID:022137895</ref><references group="xtra"/>
-[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
-[[Category: Escherichia coli]]
-[[Category: Bacher, A.]]
-[[Category: Eisenreich, W.]]
-[[Category: Graewert, T.]]
-[[Category: Groll, M.]]
-[[Category: Span, I.]]
-[[Category: 3fe-4s iron-sulfur cluster]]
-[[Category: Conserved cysteine]]
-[[Category: Ipp and dmapp production final step]]
-[[Category: Low activity]]
-[[Category: Non-mevalonate pathway]]
-[[Category: Oxidoreductase]]
-[[Category: Substrate hmbpp]]