3su0: Difference between revisions

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[[Image:3su0.jpg|left|200px]]


{{STRUCTURE_3su0| PDB=3su0 | SCENE= }}
==Crystal structure of NS3/4A protease variant R155K in complex with danoprevir==
<StructureSection load='3su0' size='340' side='right'caption='[[3su0]], [[Resolution|resolution]] 1.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3su0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SU0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.159&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TSV:(2R,6S,12Z,13AS,14AR,16AS)-6-[(TERT-BUTOXYCARBONYL)AMINO]-14A-[(CYCLOPROPYLSULFONYL)CARBAMOYL]-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-2-YL+4-FLUORO-2H-ISOINDOLE-2-CARBOXYLATE'>TSV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3su0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3su0 OCA], [https://pdbe.org/3su0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3su0 RCSB], [https://www.ebi.ac.uk/pdbsum/3su0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3su0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A8DG50_9HEPC A8DG50_9HEPC]


===Crystal structure of NS3/4A protease variant R155K in complex with danoprevir===
==See Also==
 
*[[Virus protease 3D structures|Virus protease 3D structures]]
{{ABSTRACT_PUBMED_22910833}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Hepatitis C virus genotype 1a]]
[[3su0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SU0 OCA].
[[Category: Large Structures]]
[[Category: Hepatitis c virus subtype 1a]]
[[Category: Romano KP]]
[[Category: Romano, K P.]]
[[Category: Schiffer CA]]
[[Category: Schiffer, C A.]]
[[Category: Drug design]]
[[Category: Drug resistance]]
[[Category: Hcv]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Ns3]]
[[Category: Protease inhibitor]]
[[Category: Serine protease]]

Latest revision as of 16:07, 14 March 2024

Crystal structure of NS3/4A protease variant R155K in complex with danoprevirCrystal structure of NS3/4A protease variant R155K in complex with danoprevir

Structural highlights

3su0 is a 1 chain structure with sequence from Hepatitis C virus genotype 1a. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.159Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A8DG50_9HEPC

See Also

3su0, resolution 1.16Å

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