3sfm: Difference between revisions

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-[[Image:3sfm.png|left|200px]]
-<!--
+==Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure==
-The line below this paragraph, containing "STRUCTURE_3sfm", creates the "Structure Box" on the page.
+<StructureSection load='3sfm' size='340' side='right'caption='[[3sfm]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3sfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFM FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
-{{STRUCTURE_3sfm|  PDB=3sfm  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfm OCA], [https://pdbe.org/3sfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sfm RCSB], [https://www.ebi.ac.uk/pdbsum/3sfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfm ProSAT]</span></td></tr>
+</table>
-===Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure===
+== Function ==
+[https://www.uniprot.org/uniprot/DYR21_ECOLX DYR21_ECOLX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
-<!--
-The line below this paragraph, {{ABSTRACT_PUBMED_22102224}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 22102224 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_22102224}}
-==About this Structure==
-[[3sfm]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFM OCA].
 ==See Also==
-*[[Dihydrofolate reductase]]
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:022102224</ref><references group="xtra"/>
-[[Category: Dihydrofolate reductase]]
 [[Category: Escherichia coli]]
-[[Category: Berghuis, A M.]]
+[[Category: Large Structures]]
-[[Category: Yachnin, B J.]]
+[[Category: Berghuis AM]]
-[[Category: Antibiotic resistance]]
+[[Category: Yachnin BJ]]
-[[Category: Dhf and nadph-binding]]
-[[Category: Dihydrofolate reductase]]
-[[Category: In situ proteolysis]]
-[[Category: Oxidoreductase]]
-[[Category: Reductase]]
-[[Category: Sh3]]
-[[Category: Type ii dhfr]]