3s8s: Difference between revisions

Latest revision as of 15:50, 14 March 2024

Crystal structure of the RRM domain of human SETD1ACrystal structure of the RRM domain of human SETD1A

Structural highlights

3s8s is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.3Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SET1A_HUMAN Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.^[1]

References

↑ Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 2003 Apr 1;17(7):896-911. PMID:12670868 doi:10.1101/gad.252103

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OCA

[1] Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 2003 Apr 1;17(7):896-911. PMID:12670868 doi:10.1101/gad.252103

[1]

@@ Line 1: / Line 1: @@
-[[Image:3s8s.png|left|200px]]
-{{STRUCTURE_3s8s|  PDB=3s8s  |  SCENE=  }}
+==Crystal structure of the RRM domain of human SETD1A==
+<StructureSection load='3s8s' size='340' side='right'caption='[[3s8s]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-===Crystal structure of the RRM domain of human SETD1A===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3s8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8S FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-[[3s8s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8S OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8s OCA], [https://pdbe.org/3s8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8s RCSB], [https://www.ebi.ac.uk/pdbsum/3s8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SET1A_HUMAN SET1A_HUMAN] Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.<ref>PMID:12670868</ref>
 ==See Also==
-*[[Histone methyltransferase|Histone methyltransferase]]
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Bian, C.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C.]]
+[[Category: Bian C]]
-[[Category: Cerovina, T.]]
+[[Category: Bountra C]]
-[[Category: Chao, X.]]
+[[Category: Cerovina T]]
-[[Category: Edwards, A M.]]
+[[Category: Chao X]]
-[[Category: Min, J.]]
+[[Category: Edwards AM]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Min J]]
-[[Category: Tempel, W.]]
+[[Category: Tempel W]]
-[[Category: Walker, J R.]]
+[[Category: Walker JR]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Chromatin modification]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Transcription]]
-[[Category: Transcription regulation]]

3s8s: Difference between revisions

Latest revision as of 15:50, 14 March 2024

Crystal structure of the RRM domain of human SETD1ACrystal structure of the RRM domain of human SETD1A

Structural highlights

Function

See Also

References

Contents

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3s8s: Difference between revisions

Latest revision as of 15:50, 14 March 2024

Crystal structure of the RRM domain of human SETD1ACrystal structure of the RRM domain of human SETD1A

Structural highlights

Function

See Also

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search