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==Specific recognition of N-acetylated substrates and domain flexibility in WbgU: a UDP-GalNAc 4-epimerase==
==Specific recognition of N-acetylated substrates and domain flexibility in WbgU: a UDP-GalNAc 4-epimerase==
<StructureSection load='3ru7' size='340' side='right' caption='[[3ru7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3ru7' size='340' side='right'caption='[[3ru7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ru7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_shigelloides"_(bader_1954)_ewing_et_al._1961 "aeromonas shigelloides" (bader 1954) ewing et al. 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RU7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ru7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plesiomonas_shigelloides Plesiomonas shigelloides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RU7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ru9|3ru9]], [[3rua|3rua]], [[3ruc|3ruc]], [[3rud|3rud]], [[3rue|3rue]], [[3ruf|3ruf]], [[3ruh|3ruh]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">wbgU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=703 "Aeromonas shigelloides" (Bader 1954) Ewing et al. 1961])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ru7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ru7 OCA], [https://pdbe.org/3ru7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ru7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ru7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ru7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ru7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ru7 OCA], [http://pdbe.org/3ru7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ru7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ru7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ru7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GNE_PLESH GNE_PLESH] Catalyzes the epimerization of UDP-N-acetylglucosamine (UDP-GlcNAc) to UDP-N-acetylgalactosamine (UDP-GalNAc). Has very low epimerase activity with UDP-Glc and UDP-Gal. Plays a role in the biosynthesis of 2-acetamino-2-deoxy-L-altruronic acid, a building block of the O-antigen in bacterial lipopolysaccharide (LPS).<ref>PMID:12484781</ref> <ref>PMID:21810411</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bhatt, V S]]
[[Category: Large Structures]]
[[Category: Guan, W]]
[[Category: Plesiomonas shigelloides]]
[[Category: Wang, P G]]
[[Category: Bhatt VS]]
[[Category: 4-epimerase]]
[[Category: Guan W]]
[[Category: Epimerase]]
[[Category: Wang PG]]
[[Category: Isomerase]]
[[Category: Rossmann fold]]
[[Category: Udp-galnac]]
[[Category: Udp-hexose 4-epimerase]]
[[Category: Udp-hexose]]

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