3rn2: Difference between revisions

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-'''Unreleased structure'''
-The entry 3rn2 is ON HOLD
+==Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors==
+<StructureSection load='3rn2' size='340' side='right'caption='[[3rn2]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-Authors: Jin, T.C., Xiao, T
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3rn2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RN2 FirstGlance]. <br>
-Description: Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn2 OCA], [https://pdbe.org/3rn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rn2 RCSB], [https://www.ebi.ac.uk/pdbsum/3rn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rn2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jin TC]]
+[[Category: Xiao T]]