3rcg: Difference between revisions

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-[[Image:3rcg.jpg|left|200px]]
-<!--
+==Human cyclophilin D complexed with dimethylformamide==
-The line below this paragraph, containing "STRUCTURE_3rcg", creates the "Structure Box" on the page.
+<StructureSection load='3rcg' size='340' side='right'caption='[[3rcg]], [[Resolution|resolution]] 0.97&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3rcg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RCG FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.97&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene></td></tr>
-{{STRUCTURE_3rcg|  PDB=3rcg  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rcg OCA], [https://pdbe.org/3rcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rcg RCSB], [https://www.ebi.ac.uk/pdbsum/3rcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rcg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>
-===Human Cyclophilin D Complexed with a Fragment===
+==See Also==
+*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-[[3rcg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RCG OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Peptidylprolyl isomerase]]
+[[Category: Large Structures]]
-[[Category: Ahmed-Belkacem, H.]]
+[[Category: Ahmed-Belkacem H]]
-[[Category: Bessin, Y.]]
+[[Category: Bessin Y]]
-[[Category: Colliandre, L.]]
+[[Category: Colliandre L]]
-[[Category: Guichou, J F.]]
+[[Category: Guichou JF]]
-[[Category: Pawlotsky, J M.]]
+[[Category: Pawlotsky JM]]
-[[Category: Beta barrel]]
-[[Category: Inhibitor]]
-[[Category: Isomerase-isomerase inhibitor complex]]
-[[Category: Mitochondria]]
-[[Category: Prolyl cis/trans isomerase]]