3raw: Difference between revisions
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==Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41== | |||
<StructureSection load='3raw' size='340' side='right'caption='[[3raw]], [[Resolution|resolution]] 2.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3raw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RA:5-(1,3-BENZODIOXOL-5-YLMETHYL)-2-(PHENYLAMINO)-4H-IMIDAZOL-4-ONE'>3RA</scene></td></tr> | ||
[[3raw]] is a 2 chain structure | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3raw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raw OCA], [https://pdbe.org/3raw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3raw RCSB], [https://www.ebi.ac.uk/pdbsum/3raw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3raw ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref> | |||
==See Also== | ==See Also== | ||
*[[Dual specificity protein kinase|Dual specificity protein kinase]] | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bazureau | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bazureau JP]] | ||
[[Category: Bullock | [[Category: Bountra C]] | ||
[[Category: Carreaux | [[Category: Bullock A]] | ||
[[Category: Debdab | [[Category: Carreaux F]] | ||
[[Category: Debdab M]] | |||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Fedorov | [[Category: Fedorov O]] | ||
[[Category: Filippakopoulos | [[Category: Filippakopoulos P]] | ||
[[Category: King | [[Category: King O]] | ||
[[Category: Knapp | [[Category: Knapp S]] | ||
[[Category: Meijer | [[Category: Meijer L]] | ||
[[Category: Muniz | [[Category: Muniz JRC]] | ||
[[Category: Renault | [[Category: Renault S]] | ||
[[Category: Weigelt J]] | |||
[[Category: Weigelt | [[Category: Von Delft F]] | ||
[[Category: | |||